Which immune cells primarily secrete IFN-alpha?

Dendritic cells primarily secrete IFN-alpha, a type of interferon that plays a crucial role in the immune response, particularly in the context of viral infections. These cells are professional antigen-presenting cells that not only capture and process antigens but also produce various cytokines to help activate other immune cells. When dendritic cells encounter viruses, they respond by secreting IFN-alpha, which can enhance the antiviral responses of nearby cells, promoting the overall immune defense.

This secretion supports the activation of T cells and enhances the cytotoxicity of Natural Killer cells, creating a heightened state of alert in the immune system against potential viral threats. This specific functionality distinguishes dendritic cells from other immune cells that also play important roles but do not primarily produce IFN-alpha.