Which B-cell neoplasm type develops when the Epstein-Barr virus infects B cells and causes specific genetic changes?

Burkitt's lymphoma is specifically associated with the Epstein-Barr virus (EBV) because the virus can lead to genetic alterations in B cells. These changes typically result in the activation of oncogenes and the inactivation of tumor suppressor genes, which can drive the development of this aggressive B-cell malignancy. In particular, Burkitt's lymphoma is often linked to a chromosomal translocation involving the MYC gene, which is pivotal for cell proliferation. The interaction between EBV and the immune response plays a crucial role in the pathogenesis of Burkitt's lymphoma, especially in endemic forms commonly found in African children, where patterns of infection with EBV and malaria coalesce to heighten risk.

Other B-cell neoplasms like Hodgkin's lymphoma and multiple myeloma do not exhibit the same direct association with the Epstein-Barr virus in their pathogenesis, although EBV may be present in some cases of Hodgkin's lymphoma. Non-Hodgkin's lymphoma is a broader category that includes various types of lymphomas, not all of which are specifically tied to EBV-related genetic changes. Thus, the direct link between EBV infection and genetic alterations leading to Burkitt's lymphoma makes it the correct answer