What is the role of short-chain fatty acids produced by skin staphylococci?

Short-chain fatty acids (SCFAs) produced by skin staphylococci play a significant role in inhibiting the growth of pathogens, which supports the overall health of the skin. These fatty acids are a byproduct of the fermentation of dietary fibers and have antimicrobial properties that can help protect the skin from potentially harmful microorganisms. By creating an unfavorable environment for pathogenic bacteria, SCFAs contribute to maintaining a balanced skin microbiome, which is crucial for preventing infections and promoting skin health.

While strengthening skin barrier function, promoting hydration, and boosting immune cell production are also important aspects of skin health, the primary function of SCFAs in this context specifically relates to their ability to directly impact pathogenic growth, making them essential for the protective role of the skin's microbiome.